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Pure Appl. Chem., Vol. 70, No. 11,
pp. 2141, 1998
Novel antifungal compounds derived from heterocyclic
positional scanning combinatorial libraries*
Sylvie E. Blondelle,
Adel Nefzi, John M. Ostresh and Richard A. Houghten
Torrey Pines Institute for Molecular Studies, 3550 General Atomics
Court, San Diego, CA 92121, USA.
E-mail: [email protected]
Abstract: Synthetic combinatorial libraries composed of mixtures
of tens thousands to millions of compounds have been shown to be
useful in a wide range of biomedical research areas. The "libraries
from libraries" concept was extended to the generation of heterocyclic
synthetic combinatorial libraries from existing N-acylated dipeptide
libraries. In particular, N-alkyl aminocyclic urea and thiourea
SCLs were generated and assayed for their ability to inhibit Candida
albicans growth. Potent individual anticandidal compounds were
derived from these libraries.
Download full text (8
pages) - PDF file (64KB)
* Invited lecture presented at the International
Conference on Bioversity and Bioresources: Conservation and
Utilization, 23-37 November 1997, Phuket, Thailand.
Page last modified 23 April 1999.
Copyright ©1997, 98, 99 International Union of Pure and Applied
Chemistry.
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