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Pure Appl. Chem., Vol. 70, No. 11,
pp. 2140, 1998
Combinatorial libraries for studying molecular
recognition*
Gordon Lowe, Susanna Leon and Rachel Quarell
Dyson Perrins Laboratory, Oxford University, South Parks Road, Oxford,
OX1 3QY, UK
E-mail: [email protected]
Abstract: Combinatorial Libraries have great potential for
studying biomolecular recognition. They consist of large numbers
of structurally diverse compounds which can be generated rapidly.
The key to their use is in the development of selection assays which
allow the most active compounds to be identified. The most commonly
used selection procedures are based on binding, the compound(s)
with the highest affinity being isolated and identified. In this
report some fundamental questions concerning the assaying of libraries
on solid supports by enzyme catalysis are addressed.
Download full text (7 pages)
- PDF file (73KB)
* Invited lecture presented at the International
Conference on Bioversity and Bioresources: Conservation and
Utilization, 23-37 November 1997, Phuket, Thailand.
Page last modified 14 April 1999.
Copyright ©1997, 98, 99 International Union of Pure and Applied
Chemistry.
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