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Pure Appl. Chem., Vol. 70, No. 11,
pp. 2119, 1998
Chasing the key enzymes of secondary metabolite
- Biosynthesis from Thai medicinal plants*
Wanchai
De-Eknamkul
Department of Pharmacognosy, Faculty of Pharmaceutical Sciences,
Chulalongkorn University, Bangkok 10330, Thailand
E-mail: [email protected]
Abstract: Novel enzymes involved in the biosynthesis of plant
secondary metabolites have been discovered in our laboratory from
both differentiated plants and in vitro cultures of Thai
medicinal plants. The discovered enzymes included (1) geranylgeraniol-18-hydroxylase
from Croton sublyratus containing plaunotol, an anti-peptic
ulcer diterpenoid, (2) dopamine-secologanin condensing enzymes from
Alangium lamarckii containing emetine, an amoebicidal tetrahydroisoquinoline
monoterpene alkaloid, (3) lawsone-forming multienzyme complex from
Impatiens balsamina root cultures containing lawsone, an
antimicrobial naphthoquinone, and (4) 1,2-dehydroreticuline reductase
from Papaver somniferum seedlings containing morphinan alkaloids.
Each of these enzymes was isolated, partially purified, characterized
and evaluated for its role involved in the biosynthetic pathway
of each secondary metabolite accumulated in its producing plant.
Download full text
(14 pages) - PDF file (120KB)
* Invited lecture presented at the International
Conference on Bioversity and Bioresources: Conservation and
Utilization, 23-37 November 1997, Phuket, Thailand.
Page last modified 27 February 1999.
Copyright ©1997, 98, 99 International Union of Pure and Applied
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