Postgenomic chemistry: New problems and challenges
S. D. Varfolomeyev, T. K. Aliev, and E. N. Efremenko
The Lomonosov Moscow State University, Faculty of
Chemistry, Chemical Enzymology Department, Lenin�s Hills, 1/11, Moscow
119992, Russia
Abstract: New trends in chemistry induced by genetic engineering
and genomic information are analyzed. Genomic information and bioinformatics
make the identification of all molecular participants of biological
processes possible. The methods of identification of enzyme-active sites
from sequence data were demonstrated. The problems of "chemical proteomics"
were formulated and analyzed. New biocatalytic processes based on a
new generation of enzymes, including CO2 reduction and enzyme
fuel cell construction, are demonstrated. It was shown that in many
reactions the enzymes are substantially more efficient in comparison
with classical chemical catalysts. The creation of recombinant proteins
from unnatural amino acids is demonstrated, and organisms containing
such proteins are described. The new trends of proteomics and bioanalytical
chemistry in the postgenomic era are discussed.
*Plenary lecture presented at the XVII Mendeleev Congress on General and Applied Chemistry, Kazan, Tatarstan, Russia, 21 -26 September 2003. Other presentations are published in this issue, pp. 1605-1798.
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