NO donors: Focus on furoxan derivatives
A. Gasco, R. Fruttero, G. Sorba, A. Di Stilo, and R. Calvino
Dipartimento di Scienza e Tecnologia del Farmaco,
Università degli Studi di
Torino, via P. Giuria 9, I-10125 Torino, Italy; Dipartimento di Scienze
Alimentari, Farmaceutiche e Farmacologiche, Università degli
Studi del Piemonte Orientale, via Bovio 6, I-28100 Novara, Italy
Abstract: The article focuses attention on furoxan derivatives
(1,2,5 oxadiazole 2-oxides) as NO donors. Possible mechanisms for NO
release from these products in physiological solution and in segments
of rabbit femoral artery are briefly considered. The in vitro anti aggregatory
activities and the in vitro and in vivo vasodilating properties of a
number of furoxans are examined with particular reference to involvement
of NO in these actions. The use of the furoxan system to design new
NO donor/drug hybrids is discussed in connection with the problem of
the balance between NO- and drug dependent activities of the resulting
structures. Whether other biological activities (as yet, little studied)
of furoxans, such as their antiparasite, antimicrobial, and antitumoral
effects, are NO dependent, is a matter still to be explored.
*Lecture presented at the Polish-Austrian-German-Hungarian-Italian Joint Meeting on Medicinal Chemistry, Kraków, Poland, 15-18 October 2003. Other presentations are published in this issue, pp. 907 -1032.
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