Discovery of new anti-inflammatory agents
F. Fülöp, L. Lázár, Z. Szakonyi, M. Pihlavisto, S. Alaranta, P. J. Vainio, A. Juhakoski, A. Marjamäki, and D. J. Smith
Institute of Pharmaceutical Chemistry, University
of Szeged, Eötvös u.6, H-6720 Szeged, Hungary; Biotie Therapies
Corporation, Tykistökatu 6, FIN-20520 Turku, Finland
Abstract: We have synthesized a series of novel hydrazines and
hydrazino alcohols that specifically inhibit vascular adhesion protein-1
(VAP-1), a human endothelial cell adhesion molecule with a well documented
role in inflammation. VAP-1 is a semicarbazide-sensitive amine oxidase
(SSAO), and the enzyme activity has been demonstrated to have a role
in VAP-1 function. An indane hydrazino alcohol was able to reduce clinical
symptoms of inflammation in experimental arthritis in rodents and has
the potential to be a novel anti-inflammatory drug.
*Lecture presented at the Polish-Austrian-German-Hungarian-Italian Joint Meeting on Medicinal Chemistry, Kraków, Poland, 15-18 October 2003. Other presentations are published in this issue, pp. 907 -1032.
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