Spacer conformation in biologically active molecules
J. Karolak-Wojciechowska and A. Fruzinski
Institute of General and Ecological Chemistry, Technical
University, Lódz , Poland
Abstract: Based on our contemporary studies on the structures
of biologically active molecules, we focus our attention on the aliphatic
chain and its conformation. That flexible spacer definitely influenced
the balanced position of all pharmacophoric points in molecules of bi-
ological ligands. The one atomic linker and two or three atomic spacers
with one heteroatom X =O, S, CH2, NH have been taken into
account. The conformational preferences clearly depend on the heteroatom
X. In the discussion, we utilize our own X-ray data, computation chemistry
methods, population analysis, and statistical data from the Cambridge
Structural Database (CSD).
*Lecture presented at the Polish-Austrian-German-Hungarian-Italian Joint Meeting on Medicinal Chemistry, Kraków, Poland, 15-18 October 2003. Other presentations are published in this issue, pp. 907 -1032.
Page last modified 8 July 2004.
Copyright © 2004 International Union of Pure and Applied Chemistry.
Questions or comments about IUPAC, please contact, the Secretariat.
Questions regarding the website, please contact web