Neuropeptide mimetics for pain management
A. W. Lipkowski, A. Misicka, D. B. Carr, G. Ronsisvalle, D. Kosson, and I. Maszczynska Bonney
Medical Research Centre, Polish Academy of Sciences,
02106 Warsaw, Poland; Department of Chemistry, Warsaw University, 02-093
Warsaw, Poland; Tufts-New England Medical Center, Boston, MA 02111,
USA; Department of Pharmaceutical Sciences, University of Catania, 95125
Catania, Italy; Department of Anesthesia and Intensive Care, Medical
School, Warsaw, Poland
Abstract: The discovery of numerous endogenous neuropeptides
that participate in the formation, transmission, modulation, and perception
of pain signals offers numerous strategies for the development of new
analgesics. Nevertheless, the same research has not yet replaced
opioids as the gold standard of pain treatment. Therefore, one possible
avenue of drug development may shift interest from searching for receptor-selective
opioids to creating an arsenal of drugs that target multiple opioid
and non-opioid sites simultaneously. The presented short review focuses
on the development of potential analgesic peptidomimetic compounds based
upon opioid neuropeptides and substance P.
*Lecture presented at the Polish-Austrian-German-Hungarian-Italian Joint Meeting on Medicinal Chemistry, Kraków, Poland, 15-18 October 2003. Other presentations are published in this issue, pp. 907 -1032.
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