Progress in fumagillin synthesis
W. Picoul, O. Bedel, A. Haudrechy, and Y. Langlois
Laboratoire de Synthèse des Substances Naturelles,Associé
au CNRS, Université de Paris-Sud, F-91405 Orsay, France
Abstract: After a brief account of the syntheses previously
described in literature, several approaches of the antiangiogenic sesquiterpene
fumagillin are described. Particularly, a ClaisenIreland ring-closing
metathesis strategy allowed the stereoselective preparation of several
advanced intermediates in the fumagillin synthesis.
*Pure Appl.Chem. 75,
141�419 (2003). An issue of reviews and research papers based on
lectures presented at the 23rd IUPAC International Symposium on the
Chemistry of Natural Products, Florence, Italy, 28 July � 2 August 2002.
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