New cyclization reactions in organic syntheses*
Iwao Ojima
Department of Chemistry, State University of New York
at Stony Brook, Stony Brook, NY 11794-3400, USA
Abstract: Recent development in the transition metal-catalyzed
cyclization reactions for organic syntheses in the author's laboratories
is summarized, which includes (i) novel silylcarbocyclizations (SiCaCs)
and carbonylative carbotricyclizations, (ii) intramolecular silylformylations
and desymmerization of siloxydiynes by sequential double silylformylation,
(iii) efficient total synthesis of (+)-prosopinine, (iv) enantioselective
desymmetrization of aminodienes, and (iv) new and efficient routes to
1-azabicyclo[x.y.0]alkane amino acids. All these processes are catalyzed
by Rh or RhCo complexes, and useful for rapid and efficient construction
of a variety of heterocyclic and carbocyclic compounds. Mechanisms of
these new carbocyclization and cyclohydrocarbonylation reactions are
also discussed.
*Lecture presented at the 11th IUPAC International
Symposium on Organometallic Chemistry Directed Towards Organic Synthesis
(OMCOS-11), Taipei, Taiwan, 22-26 July 2001. Other presentations are
presented in this issue, pp.1-186.
**Corresponding author.
Page last modified 21 March 2002.
Copyright © 2002 International Union of Pure and Applied Chemistry.
Questions or comments about IUPAC, please contact, the Secretariat.
Questions regarding the website, please contact web
manager.
