Functionalized main-group organometallics for organic synthesis*
Paul Knochel, Eike Hupe, Wolfgang Dohle, David M. Lindsay, Véronique
Bonnet, Guy Quéguiner, Andreas Boudier, Felix Kopp, Stéphane
Demay, Naka Seidel, M. Isabel Calaza, Viet Anh Vu,Ioannis Sapountzis,
and Tanasri Bunlaksananusorn
Ludwig-Maximilians-Universität München, Department
Chemie, Butenandtstrasse 5-13, Haus F, 81377 München, Germany
Abstract: Highly functionalized Grignard-reagents can be easily
obtained by an iodinemagnesim exchange reaction and further reacted
with various electrophiles. Via a BZn exchange reaction, a formal
Michael addition with umpolung of the reactivity can be achieved. Chiral
phosphine ligands can be easily synthesized by a 2.3 sigmatropic rearrangement
and used successfully in asymmetric synthesis.
*Lecture presented at the 11th IUPAC International
Symposium on Organometallic Chemistry Directed Towards Organic Synthesis
(OMCOS-11), Taipei, Taiwan, 22-26 July 2001. Other presentations are
presented in this issue, pp.1-186.
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