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Pure Appl. Chem. Vol.
73, No. 10, pp. 1573-1577 (2001)
Pure and Applied Chemistry
Vol. 73, Issue 10
Threading intercalation to double-stranded DNA and the application
to DNA sensing. Electrochemical array technique*
Department of Applied Chemistry, Faculty of Engineering,
Kyushu University, Higashi, Fukuoka, Japan
Abstract: Electrochemical labeling of double-stranded (ds) DNA
is achieved by redox-active DNA intercalators. Threading intercalators
derived from naphthalenediimide appended with ferrocene reporter group
in the side arms are particularly useful for this purpose. This allows
a sensitive electrochemical detection of DNA hybridization on an array,
providing a great potential for low-cost, high-throughput, and quick
DNA screening technique in post-genome study.
*Lecture presented at the IUPAC International Congress
on Analytical Sciences 2001 (ICAS2001), Tokyo, Japan, 6-10 August 2001.
Other presentations are published in this issue,
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