Crystalline inclusion complexes as media of molecular recognitions
and selective reactions*
Fumio Toda
Department of Chemistry, Faculty of Science, Okayama
University of Science, Ridai-cho 1-1, Okayama, 700-0005, Japan
Abstract: Hexaol host compounds which include guest molecules
maximum in 1:6 ratio were prepared. Aromatic hexaol host, hexahydroxytriphenylene,
was found to form chiral inclusion crystal by complexation with achiral
guest molecules. Some interesting and important optical resolutions
of rac-guests by inclusion complexation with a chiral host were described.
When chemical reaction and the inclusion complexation procedures in
a water suspension medium are combined, new economical and ecological
method of the preparation of optically active compound can be established.
When photochemical reactions are carried out in an inclusion crystal
with a chiral host, enantioselective reactions occur, and optically
active product can be obtained. Several successful reactions are described.
*Lecture presented at the 38th IUPAC Congress/World
Chemistry Congress 2001, Brisbane, Australia, 1-6 July 2001. Other presentations
are published in this issue, pp.1033-1145.
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