Vital role of entropy in photochirogenesis*
Yoshihisa Inoue1,2,**, Norimitsu Sugahara2, and Takehiko Wada2
1Inoue Photochirogenesis Project, ERATO, JST, 4-6-3
Kamishinden, Toyonaka 565-0085, Japan
Abstract: The effects of temperature, pressure, solvent, and
substrate concentration upon several enantio- and diastereodifferentiating
photochemical reactions have been investigated and discussed in detail.
These entropy-related external factors, which manipulate the weak electronic
and steric interactions in the excited state, dynamically control the
stereochemical outcome of asymmetric photochemical reactions, and even
switch the product chirality. A global view on the "entropy chemistry"
and its potential applications are also discussed.
*Lecture presented at the XVIIIth IUPAC Symposium on
Photochemistry, Dresden, German , 22-27 July 2000.Other presentations
are published in this issue, pp.395-548.
**Corresponding author
