Species-selective determination of selenium compounds in biological
materials (Technical Report)
R. Lobinski1,2
, J. S. Edmonds3 , K. T. Suzuki4 , and P. C. Uden5
1Warsaw University
of Technology, Faculty of Chemistry, Department of Analytical Chemistry,
ul. Noakowskiego 3, 00-664 Warszawa, Poland; 2CNRS UMR 5034,
Hélioparc, 2, av. Pr. Angot, 64 000 Pau, France; 3Department
of Chemistry, De Montfort University, The Gateway, Leicester LE1 9BH,
UK; 4Faculty of Pharmaceutical Sciences, Chiba University,
Inage, Chiba 263-8522, Japan; 5Department of Chemistry, University
of Massachusetts, Amherst, MA 01003-4510, USA
Abstract: There is substantial evidence of the complexity of
selenium speciation in living organisms and of the importance of the
selective determination of the particular species of this element in
order to understand its metabolism and biological significance in clinical
chemistry, biology, toxicology, and nutrition. The state-of-the-art
of analytical techniques available for this purpose is critically evaluated
with particular emphasis on the element-selective detection and identification
of the detected selenium compounds. Whereas there are a number of techniques
available that are able to detect various selenium species in living
organisms selectively, few techniques exist that are able to identify
and to characterize the species detected.
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