B. M. Trost
Blackwell Science,1994 [ISBN 0865428336]
Synthetic organic chemistry is currently advancing
in many new and exciting directions. Formation of C-H, C-O and C-C bonds
with high diastero- and enantio-selectivity is still emerging, and as
methods such as these develop, sythetic strategies to complex organic
molecules follow. By being able to make structural entities at will,
the prospect for understanding molecular function, especially biological
function, increases. In this multi-author volume, leading practitioners
from around the world explore
contemporary issues in synthetic organic chemistry and discuss their
implications for the future. Synthetic efficiency is the underlying
theme of the contributions, with stereocontrol the major issue. A state-of-the-art
summary for all synthetic organic chemists
Contents
Binapthyls as chiral elements for asymmetric
synthesis; Chiral titanium complex in asymmetric construction of carbon
skeletons; Chiral Lewis acids as efficient catalysts in asymmetric synthesis;
Enantioselective reactions using chiral lithium amides; Organometallic
compounds for selective C-C bond formation and for molecular recognition;
Synergistic effects of heteroatoms in organic synthesis; Chiral auxillary
based C-C bond forming reactions; Stereocontrolled synthesis of functionalized
cyclohexanes via Diels-Alder cycloadditions of 2-pyrones and 2-pyridines;
Adventures in cycloaddition reactions: past, present and future; Asymmetric
synthesis using main group allylmetal reagents: remote asymmetric induction
using allylstannanes; Stereoselective synthesis of polypeptide natural
products, achievements and future development; Directed and predictable
stereoselectivity results and future goals; New strategy for steroid
synthesis based on Pd catalyzed regio and stereoselective hydrogenolynes
and elimination reactions of allylic carbonates and formates; Stereocontrolled
construction of cyclooctanoid natural products by claisen-based ring
expansion; Synthesis of optically active pyrethroids; Biocatalytic methods
for enantioselective synthesis; Asymmetric synthesis based on enzymes;
Enantioselective sulfoxidations catalyzed heme-dependent monooxygenases;
Asymmetry in bioorganic chemistry - its importance and usefulness; Stereochemical
aspects of antitumor activity of bleomycin
113 illustrations
496 pages
© 1998 Blackwell Science
Ltd