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Project
Number: 2005-034-1-300
Title: Development of methodologies and protocols for
documentation, evaluation of safety and efficacy and standardization
of herbal medicine
Task Group
Chairman: M.
Mosihuzzaman
Members: A
K Azad Khan, Ermias
Dagne, M Iqbal
Choudhury, Bilge
Sener, Gurib-Fakim
Ameenah, H Wagner,
G N Qazi, Mohamed
H Farah, Kurt
Hostettmann, Ikhlas
A. Khan, and Zhu
Xiaoxin
Completion Date: 2008 - project completed
Objective:
Development of methodologies and protocols for the
-
Documentation of traditional knowledge of medicine
using existing information & databases and by collecting new
information from traditional healers
-
Scientific evaluation of efficacy, toxicity &
dose form of herbal/traditional medicine
-
Standardization of raw materials, intermediates
and final product of herbal medicine
Description:
Herbal/traditional medicines have been playing an important role
in the primary health care of the people around the world, specially
in the developing countries. In order to keep pace with the modern
medicines, the production of safe and effective herbal medicines
in a standardized way is essential. So also is the necessity to
document and preserve the traditional medical knowledge which is
disappearing.With the above background the necessity of establishing
a Multidisciplinary International Research Centre on Herbal Medicine
was felt.
The present Project is submitted for moving forward
in fulfilling the following aims for creating the knowledge base
necessary as a first step towards establishing such a Centre:
-
a) Development of methodologies and appropriate
protocols for carrying out systematic and proper documentation
of the existing available knowledge of traditional and folkloric
medicines, collecting new information from traditional healers
and compiling them into an easily accessible format;
-
b) Preparation of proper scientific screening
protocols for evaluating existing herbal/traditional medicines
and other preparations for their efficacy, toxicity (if any) and
dose forms using both in-vitro and in-vivo procedures; and
-
c) Development of well formatted methods for standardization
of raw materials, intermediate products and final preparations
of herbal medicine using latest techniques like NMR, HPLC, GC
etc which can be utilized for fingerprinting of active principles
in a plant material or products derived from them.
The project will be implemented through electronic
communication and finally by holding a Workshop in May-June 2006
in Dhaka, Bangladesh for outlining the methodologies and protocols
on the three areas mentioned.
Once these methodologies and protocols are in place
a nucleus for work for the Centre can begin and financial assistance
can be sought from international agencies and other interested organizations
involved in the production of herbal medicine or in drug development
from natural sources. The knowledge acquired will be available for
natural product research directed to the development of new chemical
entities into therapeutic agents.
Progress:
With support from the local scientists, the Task Group Chairman
discussed the matter with a number of reputed scientists in Europe
and America and received enthusiastic support. This was demonstrated
in the IUPAC supported Workshop
in January 2004 in New Delhi. Later, the proposal of setting
up an International Centre for Natural Product Research with emphasis
on herbal medicine has been discussed in various forums including
those of IUPAC, specially with the Organic and Biomolecular Division
in Beijing in August 2005.
With co-sponsored by the Bangladesh Academy of Science,
a workshop of the task group was held on 6-9 June 2006 in Dhaka,
Bangladesh. > Meeting
Minutes (pdf file -17KB)
Oct 2008 - Project completed - Technical Report published in Pure Appl. Chem., 2008, Vol. 80, No. 10, pp. 2195-2230
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Page last modified 4 November 2008.
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