||I U P A C
for Young Chemists
.... 2003 winners
Organizations & People
IUPAC Prize for Young
Chemists - 2003
receives one of three Honorable Mention awards associated with
the IUPAC Prize for Young Chemists, for his Ph.D. thesis work
entitled "Expanding the Genetic Code of Escherichia
Current address (at the time of application)
University of California, San Diego
CMM West 310, Mail Code: 0647
9500 Gilman Drive, La Jolla, CA 92093-0647, USA
Ph.D. University of California at Berkeley, Bioorganic
Chemistry, May 2002
M.S. Peking University, Physical Chemistry, July
B.S. Peking University, Organic Chemistry, July
Title Expanding the Genetic Code of Escherichia coli
Advisers Prof. Peter G. Schultz
Thesis Committee Prof. Jonathan A. Ellman, Department of Chemistry,
University of California at Berkeley; Prof. Jasper D. Rine, Deparment
of Molecular and Cell Biology, University of California at Berkeley.
The genetic code of virtually every known organism, from bacterium
to human, encodes the same twenty common amino acids. Only in rare
instances, selenocysteine or pyrrolysine is used. Nonetheless, it
is remarkable that polypeptides synthesized from these simple building
blocks can carry out all of the complex processes of life, from photosynthesis
and vision to signal transduction and the immune response. Could the
genetic code be expanded to include additional amino acids? Could
the properties of proteins, or possibly an entire organism, be enhanced
by new amino acids with novel chemical, structural or physical properties?
My dissertation focused on the development of a general strategy that
makes it possible to incorporate unnatural amino acids site-specifically
into proteins directly in living cells, and the application of these
genetically encoded novel amino acids.
Full text essay [pdf file - 351KB]
Page last modified 29 April 2003.
Copyright ©2003 International Union of Pure and Applied Chemistry.
Questions or comments about IUPAC, please contact, the Secretariat.
Questions regarding the website, please contact Web