43rd IUPAC Council Meeting
Nominee for Vice President
Nicole J. Moreau
(France)
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Nicole J. Moreau
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After 10 years of research in organic synthesis, terpenes, steroids,
and sugars, Professor Nicole J. Moreau successfully designed the first
purification, using affinity chromatography, of enzymes that inactivate
aminoglycoside antibiotics. Her research is at the interface of chemistry
and life sciences, and she continues to study the mode of action of
antibiotics and the ways bacteria can resist them. She developed a mean
throughput screening system in order to find molecules able to be active
against resistant bacteria, for instance inhibitors of efflux pumps
or of inactivating enzymes. She has also researched molecular pharmacology,
structure-activity relationships and synthesis of analogues of active
compounds together with molecular modeling and docking calculations.
In 2005, she launched, together with CNRS and Rhodia, a new program
on fine chemistry using bioconversions.
Education and Career
Moreau received an M.S. in physical chemistry from the University of
Paris (Sorbonne). She obtained a doctorate in physical sciences (chemistry
distinction) in 1967 from Orsay University.
Since 1999, Moreau has been a professor at Ecole Nationale Supérieure
de Chimie de Paris (ENSCP), where she is the leader of the Laboratory
of Biochemistry. From 1994–1999 she was a professor in the Laboratory
of Molecular Research on Antibiotics at the Paris 6 University (Pierre
and Marie Curie). In 1973, she was a postdoctoral fellow in the laboratory
of Dr. J. S. Pitton at the Medical Microbiology Institute in Geneva,
Switzerland. Moreau began service with the Centre National de la Recherche
Scientifique (CNRS) in 1962, where she was “directeur de recherche”
from 1979 to 1992. In 1972, Moreau joined the chemistry laboratory of
Prof. Le Goffic at Ecole Normale Supérieure in Paris, where she
worked until 1993.
Moreau has authored more than 80 publications, given more than 90 conferences
or oral presentations, and supervised 25 Ph.D and 22 M.S. students and
10 post-doctoral fellows. She is responsible for teaching at the interface
of chemistry and life sciences at the Ecole Nationale Supérieure
de Chimie de Paris and is a member of the Administration Committee of
the French Society of Biochemistry and Molecular Biology.
IUPAC Activities
Since 2000, Moreau has been an elected member of the Bureau and also
a member of the Project Committee. She has served as vice president
and currently is general secretary of the French National Committee
for Chemistry. She has been a member of the French Delegation since
1995.
Related Professional Activities
Moreau has held a number of leadership positions with leading chemistry
institutions. She has served as chargé de mission, State Department
of Research (Ministère de la Recherche), deputy director of the
Drugs department (1984–1989) and has been chargé de mission
(1993–1997), then deputy director (1998–2003), at CNRS, Department
of Chemical Sciences. Since 2003, she remained chargé de mission
for natural substances for the CNRS Chemistry Department and International
Relationships Direction.
She was secretary (1989–1997), then president (1997-1999) of EUCHEM,
European Chemistry; president of GESA; Study Group of Structure-Activity
Relationships (1990); vice-president of the French National Committee
for Chemistry, CNC, IUPAC NAO (1994–2002). In addition, she is
a long-time member of the French Chemical Society, French Microbiology
Society, and the French Biochemistry and Molecular Biology Society.
Awards
Moreau was awarded the Prix de l’Académie de Pharmacie,
Paris, in 1974, and the Chevalier de l’Ordre National du Mérite,
awarded by the State Department of Research, in 2002. In 2004 she received
the Silver Medal of the International Foundation of la Maison de la
Chimie.
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at 43rd IUPAC Council Meeting
