Fifty years of "Watson-Crick"
A. M. MacMillan
Department of Biochemistry, University of Alberta,
Edmonton, Alberta T6G 2H7, Canada
Abstract: Fifty years have passed since Watson and Crick proposed
the molecular basis for the replication of nucleic acid and hence the
transfer of genetic information. During this time, a model for the expression
of this genetic information has been proposed and refined considerably.
Coincident with these advances, the chemical synthesis of oligonucleotides
combined with the power of molecular biology has facilitated dramatic
advances in our understanding of the fundamental workings of the living
cell.
*Lecture presented at the symposium "Chemistry of nucleic
acids", as part of the 39th IUPAC Congress and 86th Conference of the
Canadian Society for Chemistry: Chemistry at the Interfaces, Ottawa,
Canada, 10-15 August 2003. Other Congress presentations are published
in this issue, pp. 1295-1603.
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