Discovery of new anti-inflammatory agents
F. F�l�p, L. L�z�r, Z. Szakonyi, M. Pihlavisto, S. Alaranta, P. J. Vainio, A. Juhakoski, A. Marjam�ki, and D. J. Smith
Institute of Pharmaceutical Chemistry, University
of Szeged, Eötvös u.6, H-6720 Szeged, Hungary; Biotie Therapies
Corporation, Tykistökatu 6, FIN-20520 Turku, Finland
Abstract: We have synthesized a series of novel hydrazines and
hydrazino alcohols that specifically inhibit vascular adhesion protein-1
(VAP-1), a human endothelial cell adhesion molecule with a well documented
role in inflammation. VAP-1 is a semicarbazide-sensitive amine oxidase
(SSAO), and the enzyme activity has been demonstrated to have a role
in VAP-1 function. An indane hydrazino alcohol was able to reduce clinical
symptoms of inflammation in experimental arthritis in rodents and has
the potential to be a novel anti-inflammatory drug.
*Lecture presented at the Polish-Austrian-German-Hungarian-Italian Joint Meeting on Medicinal Chemistry, Krak�w, Poland, 15-18 October 2003. Other presentations are published in this issue, pp. 907 -1032.
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