Development of catalysts for the hydroamination of olefins
J. F. Hartwig
Department of Chemistry, Yale University, P.O.Box
208107, New Haven, CT
06520-8107, USA
Abstract: Studies on the development of palladium, nickel, and
rhodium catalysts for the hydroamination of dienes and vinylarenes are
described. Enantioselective catalysts based on palladium have been developed
for the addition of arylamines to dienes and for Markovnikov addition
of arylamines to vinylarenes. In addition, nickel catalysts for the
addition of aliphatic amines to dienes have been developed, and rhodium
catalysts for the first transition metal-catalyzed aminations of vinylarenes
that generate terminal amines as the major product are described. Mechanistic
data on the hydroamination of vinylarenes with palladium and rhodium
is also provided.
*Plenary and invited lectures presented at the 12th
International Symposium on Organometallic Chemistry Directed Towards
Organic Synthesis (OMCOS-12), Toronto, Ontario, Canada, 6-10 July 2003.
Other lectures are published in this issue, pp.
453-695.
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