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Pure Appl. Chem. 74(12), 2253-2257, 2002

Pure and Applied Chemistry

Vol. 74, Issue 12

Advances in biocatalytic synthesis. Enzyme-triggered asymmetric cascade reactions

S. M. Glueck, S. F. Mayer, W. Kroutil, and K. Faber*

Department of Chemistry, Organic and Bioorganic Chemistry, University of Graz, Heinrichstrasse 28, A-8010 Graz, Austria

Organic compounds can be transformed through enzyme-triggered domino (or cascade) reactions via several (inseparable) consecutive steps in an asymmetric fashion to yield nonracemic products. Despite the fact that these sequences often involve the occurrence of highly reactive unstable intermediates, the overall efficiency of these processes can be high, provided that the reaction rates of the individual steps match each other in order to minimize side reactions.

*Lecture presented at the IUPAC Workshop, Impact of Scientific Developments on the Chemical Weapons Convention, Bergen, Norway, 30 June-3 July 2002. Other presentations are published in this issue, pp. 2229-2322.

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