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Pure Appl. Chem. 74(11), 2213-2226, 2002

Pure and Applied Chemistry

Vol. 74, Issue 11

Recent advances in industrial carotenoid synthesis. Errata*
(this reference replaces Pure Appl. Chem. 74(8), 1369-1382 (2002), in which the figures were produced incorrectly)

Hansgeorg Ernst

Fine Chemicals Research, GVF/B ­ B 9, BASF AG D-67056 Ludwigshafen, Germany

Abstract: Symmetrical C40-carotenoids are efficiently produced by double Wittig olefination of the corrresponding C15-phosphonium salts with C10-dialdehyde. Industrial syntheses of lycopene-, astaxanthin-, and (3R,3'R)-zeaxanthin-C15-phosphonium salts are discussed. An efficient route to a monoprotected C10-dialdehyde for the synthesis of unsymmetrical

C40-carotenoids is presented. Primary polyene allyl alcohols can be converted to the corresponding aldehydes by "TEMPO" oxidation. A high-yield synthesis of meso-zeaxanthin as an example for syntheses of unsymmetrical carotenoids is presented.

*Lecture presented at the 13th International Symposium on Carotenoids, Honolulu, Hawaii, USA, 6-11 January 2002 and originally published in Pure Appl. Chem. 74(8), 1369-1382 (2002). In the original article, the figures were reproduced incorrectly; therefore, the article is being reprinted in its entirety.
Other lectures are published in this issue, pp. 1369-1477.

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