I  U  P  A  C




News & Notices

Organizations & People

Standing Committees




. . CI
. . PAC
. . Macro. Symp.

. . Books
. . Solubility Data



Links of Interest

Search the Site

Home Page


Pure Appl. Chem. Vol. 74, No. 8, pp. 1443-1450 (2002)

Pure and Applied Chemistry

Vol. 74, Issue 8

Lycopene in the treatment of prostate cancer*

Omer Kucuk1,**, Fazlul H. Sarkar1, Wael Sakr1, Fred Khachik2, Zora Djuric1, Mousumi Banerjee1, Michael N. Pollak1, John S. Bertram2, and David P. Wood, Jr.1

1Prevention Program, Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, MI 48201, USA; 2Joint Institute for Food Safety and Applied Nutrition (JIFSAN), Department of Chemistry and Biochemistry, University of Maryland, College Park, MD 20742, USA; 3Department of Medicine, McGill University and Jewish General Hospital, Montreal, Quebec H3T 1E2, Canada; 4Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HI 96813, USA

Abstract: Dietary intake of lycopene is associated with reduced risk of prostate cancer (PCa). We conducted a clinical trial in men with prostate cancer to investigate the biological and clinical effects of lycopene supplementation. Twenty-six men with prostate cancer were randomly assigned to receive a lycopene supplement or no supplement for three weeks before radical prostatectomy. Subjects in the intervention group (n = 15) were instructed to take a tomato oleoresin extract soft gel capsule (Lyc-O-Mato®, LycoRed Company, Beer Sheva, Israel) containing 15 mg lycopene, 1.5 mg phytoene, 1.5 mg phytofluene, and 5 mg tocopherol twice daily with meals. Prostatectomy specimens were evaluated for pathologic stage, Gleason score, volume of cancer, and extent of high-grade prostatic intraepithelial neoplasia (HGPIN). Biomarkers of cell proliferation and apoptosis were assessed by Western blot analysis in benign and cancerous tissue samples obtained from the prostatectomy specimens. Oxidative stress was assessed by measuring the peripheral blood lymphocyte DNA oxidation product 5-hydroxymethyl-deoxyuridine (5-OH-mdU). Plasma levels of lycopene, insulin-like growth factor-1 (IGF-1), insulin-like growth factor binding protein-3 (IGFBP-3), and prostate-specific antigen (PSA) were measured at baseline and after three weeks of study period. After the intervention, more men in the intervention group had smaller (<4 cc) tumors, organ-confined disease without involvement of surgical margins or extra-prostatic tissues, and focal involvement of the prostate with HGPIN compared to the control group. Mean plasma PSA levels were lower in the intervention group compared to the control group. This pilot study suggests that a tomato extract containing lycopene and other tomato carotenoids and phytochemicals may have a potential role in the treatment of prostate cancer. Larger clinical trials are necessary to definitively address potential uses of lycopene or tomato extract in the prevention or treatment of prostate cancer.

** Corresponding author.

*Lecture presented at the 13 th International Symposium on Carotenoids, Honolulu, Hawaii, USA, 6-11 January 2002.
Other lectures are published in this issue, pp. 1369-1477

Page last modified 18 September 2002.
Copyright © 2002 International Union of Pure and Applied Chemistry.
Questions or comments about IUPAC, please contact, the Secretariat.
Questions regarding the website, please contact web manager.