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Pure Appl. Chem. Vol. 74, No. 8, pp. 1369-1382 (2002)

Pure and Applied Chemistry

Vol. 74, Issue 8

Recent advances in industrial carotenoid synthesis*

Hansgeorg Ernst

Fine Chemicals Research, GVF/B ­ B 9, BASF AG D-67056 Ludwigshafen, Germany

Abstract: Symmetrical C40-carotenoids are efficiently produced by double Wittig olefination of the corrresponding C15-phosphonium salts with C10-dialdehyde. Industrial syntheses of lycopene-, astaxanthin-, and (3R,3'R)-zeaxanthin-C15-phosphonium salts are discussed. An efficient route to a monoprotected C10-dialdehyde for the synthesis of unsymmetrical

C40-carotenoids is presented. Primary polyene allyl alcohols can be converted to the corresponding aldehydes by "TEMPO" oxidation. A high-yield synthesis of meso-zeaxanthin as an example for syntheses of unsymmetrical carotenoids is presented.

*Lecture presented at the 13 th International Symposium on Carotenoids, Honolulu, Hawaii, USA, 6-11 January 2002.
Other lectures are published in this issue, pp. 1369-1477

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