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Pure Appl. Chem. Vol. 74, No. 7, pp. 1227-1233 (2002)

Pure and Applied Chemistry

Vol. 74, Issue 7

Search for new sulfonyl-containing glucophores*

Jaroslaw Polanski** and Krystyna Jarzembek

Department of Organic Chemistry, Institute of Chemistry, University of Silesia, PL-40-006 Katowice, Poland

Abstract: A number of sweeteners contain the sulfur atom and a sulfonyl group. In our current search for new glucophores, several new compounds containing a sulfonyl group were obtained. Synthetic targets have been found both by intuitive modifications of the structural motifs of the known sweet compounds and by the use of molecular modeling techniques. We developed the efficient synthetic routes yielding these compounds and obtained a number of these analogs. We have evaluated the taste quality of the amides and sulfonylated amino acids, finding out that almost all of them are bitter actives. We are now performing basic toxicological tests preceding the systematic taste study within the tetrazoles obtained.

* A special topic issue on the science of sweeteners.
** Corresponding author. E-mail: [email protected]

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