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Pure Appl. Chem. Vol. 74, No. 6, pp. 907-914 (2002)

Pure and Applied Chemistry

Vol. 74, Issue 6

Modeling genome structure and function*

Ram Samudrala

Department of Microbiology, University of Washington, Seattle, WA 98195-7242, USA

Abstract: The ongoing genomics revolution has led to the creation and enumeration of all the genes encoded within several organisms. The next steps are to catalog all proteins, their structures, and their functions in different contexts. At the same time, scientists have been pursuing experimental and theoretical approaches to integrate this information to gain understanding of the behavior of entire systems. In this work, we provide a framework for obtaining structures for all tractable protein sequences encoded by a genome, and using the resulting structures to aid in understanding function. Our aim is to integrate the output produced with other genomic and proteomic data to create a comprehensive picture of systems and organismal biology.

* Plenary lecture presented at the International Conference on Bioinformatics 2002: North-South Networking, Bangkok, Thailand, 6-8 February 2002. Other presentations are presented in this issue, pp. 881-914.
** Corresponding author.

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