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Pure Appl. Chem. Vol.
74, No. 6, pp. 907-914 (2002)
Pure and Applied Chemistry
Vol. 74, Issue 6
Modeling genome structure and function*
Department of Microbiology, University of Washington,
Seattle, WA 98195-7242, USA
Abstract: The ongoing genomics revolution has led
to the creation and enumeration of all the genes encoded within several
organisms. The next steps are to catalog all proteins, their structures,
and their functions in different contexts. At the same time, scientists
have been pursuing experimental and theoretical approaches to integrate
this information to gain understanding of the behavior of entire systems.
In this work, we provide a framework for obtaining structures for all
tractable protein sequences encoded by a genome, and using the resulting
structures to aid in understanding function. Our aim is to integrate
the output produced with other genomic and proteomic data to create
a comprehensive picture of systems and organismal biology.
* Plenary lecture presented at the International Conference
on Bioinformatics 2002: North-South Networking, Bangkok, Thailand, 6-8
February 2002. Other presentations are presented in this issue, pp.
** Corresponding author.
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