Functional group diversity by ruthenium-catalyzed olefin cross-metathesis*
F. Dean Toste, Arnab K. Chatterjee, and Robert H. Grubbs
The Arnold and Mabel Beckman Laboratory of Chemical
Synthesis, Division of Chemistry and Chemical Engineering, California
Institute of Technology, Pasadena, California 91125, USA
Abstract: Ruthenium-catalyzed olefin cross-metathesis tolerates
a wide range of functional groups, including phosphine-boranes, sulfides,
amines, phenols, and oxazolines. The high functional group tolerance
allows for the use of an olefin as a linchpin for the synthesis of a
variety of bi-, tri-, and tetradentate chiral ligands with a high degree
of functional group diversity.
*Lecture presented at the 11th IUPAC International
Symposium on Organometallic Chemistry Directed Towards Organic Synthesis
(OMCOS-11), Taipei, Taiwan, 22-26 July 2001. Other presentations are
presented in this issue, pp.1-186.
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