Synthesis of nucleoside analogs and new Tat protein inhibitors*
A. Ané1, G. Prestat3, G. T. Manh1, M. Thiam2, S. Josse3, M.
Pipelier3, J. Lebreton3, J. P. Pradère3, and D. Dubreuil3,**
1Laboratoire de Chimie Organique Structurale, Faculté
des Sciences et des Techniques, 22 BP 582 Abidjan 22, Côte d'Ivoire;
2Laboratoire de Synthèse Organique, Faculté des Sciences
et des Techniques, Université Cheikh Anta Diop, BP 5005 Dakar-Fann,
Sénégal; 3Laboratoire de Synthèse Organique, UMR
au CNRS 6513, Faculté des Sciences et des Techniques, 2 rue de
la Houssinière, BP 92208, 44322 Nantes 3, France
Abstract: Two studies, concerning the synthesis of original
nucleoside analogs regarded as an application of heterochemistry on
thiaazaheterocycle systems from thiaazabutadienes are discussed. The
preparation of new N- and C-nucleosides is presented. In the second
part, the discovery of aromatic polycyclic derivatives as inhibitors
of Tat protein is exposed. The work presented takes into account the
participation of African partners in further synthetic research programs
carried out in collaboration with the laboratory of Nantes.
*Lecture presented at the 8th International
Chemistry Conference in Africa (8th ICCA), 30 July-4 August 2001, Dakar,
Sénégal. Other presentations are published
in this issue, pp. 1147-1223.