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Pure Appl. Chem. Vol. 73, No. 7, pp. 1189-1196 (2001)

Pure and Applied Chemistry

Vol. 73, Issue 7


Synthesis of nucleoside analogs and new Tat protein inhibitors*

A. Ané1, G. Prestat3, G. T. Manh1, M. Thiam2, S. Josse3, M. Pipelier3, J. Lebreton3, J. P. Pradère3, and D. Dubreuil3,**

1Laboratoire de Chimie Organique Structurale, Faculté des Sciences et des Techniques, 22 BP 582 Abidjan 22, Côte d'Ivoire; 2Laboratoire de Synthèse Organique, Faculté des Sciences et des Techniques, Université Cheikh Anta Diop, BP 5005 Dakar-Fann, Sénégal; 3Laboratoire de Synthèse Organique, UMR au CNRS 6513, Faculté des Sciences et des Techniques, 2 rue de la Houssinière, BP 92208, 44322 Nantes 3, France

Abstract: Two studies, concerning the synthesis of original nucleoside analogs regarded as an application of heterochemistry on thiaazaheterocycle systems from thiaazabutadienes are discussed. The preparation of new N- and C-nucleosides is presented. In the second part, the discovery of aromatic polycyclic derivatives as inhibitors of Tat protein is exposed. The work presented takes into account the participation of African partners in further synthetic research programs carried out in collaboration with the laboratory of Nantes.

*Lecture presented at the 8th International Chemistry Conference in Africa (8th ICCA), 30 July-4 August 2001, Dakar, Sénégal. Other presentations are published in this issue, pp. 1147-1223.

**Corresponding Author


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