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Pure Appl. Chem. Vol. 73, No. 7, pp. 1173-1188 (2001)

Pure and Applied Chemistry

Vol. 73, Issue 7


From classical antimalarial drugs to new compounds based on the mechanism of action of artemisinin*

Anne Robert, Françoise Benoit-Vical, Odile Dechy-Cabaret, and Bernard Meunier

Laboratoire de Chimie de Coordination du CNRS, 205 Route de Narbonne, 31077 Toulouse Cedex 4, France

Abstract: A short review of the antimalarial drugs currently used in human clinics is reported. The molecular aspect of the different possible mechanisms of action of artemisinin is documented, including recent data on heme alkylation. The preparation and the in vitro antimalarial activity of new modular molecules named "trioxaquines" are also presented.

*Lecture presented at the 8th International Chemistry Conference in Africa (8th ICCA), 30 July-4 August 2001, Dakar, Sénégal. Other presentations are published in this issue, pp. 1147-1223.

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