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Pure Appl. Chem. Vol. 73, No. 7, pp. 1103-1111 (2001)

Pure and Applied Chemistry

Vol. 73, Issue 7


New methods for high-throughput synthesis*

Shu­ Kobayashi and Ryo Akiyama

Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan

Abstract: New methodologies for library synthesis have been developed. They are based on new carbon­carbon bond-formation reactions in the solid-phase and organic synthesis using polymer-supported catalysts. We have immobilized alkyl glyoxylate equivalents onto resins and prepared novel polymer-supported imines. We have also developed unprecedented polymer-supported catalysts such as microencapsulated scandium trifluoromethanesulfonate [MC Sc(OTf)3], osmium tetroxide (MC OsO4), and palladium triphenylphosphine [MC Pd(PPh3)] for high-throughput synthesis.

*Lecture presented at the 38th IUPAC Congress/World Chemistry Congress 2001, Brisbane, Australia, 1-6 July 2001. Other presentations are published in this issue, pp.1033-1145.

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