New methods for high-throughput synthesis*
Shu Kobayashi and Ryo Akiyama
Graduate School of Pharmaceutical Sciences, The University
of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan
Abstract: New methodologies for library synthesis have been
developed. They are based on new carboncarbon bond-formation reactions
in the solid-phase and organic synthesis using polymer-supported catalysts.
We have immobilized alkyl glyoxylate equivalents onto resins and prepared
novel polymer-supported imines. We have also developed unprecedented
polymer-supported catalysts such as microencapsulated scandium trifluoromethanesulfonate
[MC Sc(OTf)3], osmium tetroxide (MC OsO4), and palladium triphenylphosphine
[MC Pd(PPh3)] for high-throughput synthesis.
*Lecture presented at the 38th IUPAC Congress/World
Chemistry Congress 2001, Brisbane, Australia, 1-6 July 2001. Other presentations
are published in this issue, pp.1033-1145.
Back to Contents for access to full text
