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Pure Appl. Chem. Vol. 73, No. 3, pp. 623-626 (2001)

Pure and Applied Chemistry

Vol. 73, Issue 3

Studies directed toward the preparation of key intermediates for the synthesis of trisporic acids and cassiol*

María I. Colombo, Juan Zinczuk, Mirta P. Mischne, and Edmundo A. Rúveda**

Instituto de Química Orgánica de Síntesis (CONICET-UNR) Facultad de Ciencias Bioquímicas y Farmacéuticas, Casilla de Correo 991, 2000 Rosario, Argentina

Abstract: An enantioselective synthesis and resolution of the key White intermediate (3) for the synthesis of trisporic acids are described. Attempts to develop a synthetic route toward the antiulcerogenic compound cassiol (2) by an olefination reaction of 3 and an alternative sequence involving a Michael addition followed by an aldol condensation of an open substrate, are also reported.

*Lecture presented at the 22nd IUPAC International Symposium on the Chemistry of Natural Products, São Carlos, Brazil, 3-8 September 2000. Other presentations are published in this issue, pp. 549-626.
**Corresponding author


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