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Pure Appl. Chem. Vol.
73, No. 3, pp. 623-626 (2001)
Pure and Applied
Vol. 73, Issue
Studies directed toward the preparation of key intermediates for
the synthesis of trisporic acids and cassiol*
María I. Colombo, Juan Zinczuk, Mirta P. Mischne, and Edmundo
Instituto de Química Orgánica de Síntesis
(CONICET-UNR) Facultad de Ciencias Bioquímicas y Farmacéuticas,
Casilla de Correo 991, 2000 Rosario, Argentina
Abstract: An enantioselective synthesis and resolution of the
key White intermediate (3) for the synthesis of trisporic acids are
described. Attempts to develop a synthetic route toward the antiulcerogenic
compound cassiol (2) by an olefination reaction of 3 and an alternative
sequence involving a Michael addition followed by an aldol condensation
of an open substrate, are also reported.
*Lecture presented at the 22nd IUPAC International
Symposium on the Chemistry of Natural Products, São Carlos, Brazil,
3-8 September 2000. Other presentations are published in this issue,
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