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Pure Appl. Chem. Vol. 73, No. 3, pp. 589-593 (2001)

Pure and Applied Chemistry

Vol. 73, Issue 3

Bioactive compounds from coral reef invertebrates*

Tatsuo Higa**, Junichi Tanaka, Ikuko I. Ohtani, Musri Musman, Michael C. Roy, and Ikuma Kuroda

Department of Chemistry, Biology, and Marine Science, University of the Ryukyus, Nishihara, Okinawa 903-0213, Japan

Abstract: Manzamine A (1) known as a cytotoxin exhibited potent antimalarial activity with 40% recovery 60 days after single intraperitoneal (i.p.) injection against mice infected with the malaria parasite Plasmodium berghei. Pachastrisamine (6), a simple derivative of a sphingosine, isolated from a sponge, Pachastrissa sp. showed a high level of cytotoxicity. New sesquiterpene carbonimidic dichlorides and related aldehydes (8­12) have been isolated as cytotoxic constituents of the sponge Stylotella aurantium and shown to have moderate cytotoxicity. Cyclic undecapeptides, barangamides A­D (13­16), have been isolated from the sponge Theonella swinhoei. Their structures were established by spectroscopic analysis and chemical reaction.

*Lecture presented at the 22nd IUPAC International Symposium on the Chemistry of Natural Products, São Carlos, Brazil, 3-8 September 2000. Other presentations are published in this issue, pp. 549-626.
**Corresponding author


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