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Pure Appl. Chem. Vol. 73, No. 3, pp. 555-560 (2001)

Pure and Applied Chemistry

Vol. 73, Issue 3

Bioactive natural products as a potential source of new pharmacophores. A theory of memory*

Atta-ur-Rahman** and M. Iqbal Choudhary

International Centre for Chemical Sciences, H.E.J. Research Institute of Chemistry, University of Karachi, Karachi-75270, Pakistan

Abstract: The plant kingdom offers a rich source of structural biodiversity in the form of a variety of natural products. Our work on new bioactive compounds from medicinal plants has led to the isolation and structure elucidation of a number of exciting new pharmacophores. Bioassay-guided fractionation has recently led to the discovery of a series of new acetylcholinesterase, urease and a-glucosidase inhibitors, antioxidants and other classes of bioactive compounds, which will be presented. A theory based on hydrogen bonding on the chemical basis of memory storage in the brain is presented.

*Lecture presented at the 22nd IUPAC International Symposium on the Chemistry of Natural Products, São Carlos, Brazil, 3-8 September 2000. Other presentations are published in this issue, pp. 549-626.
**Corresponding author


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