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Pure Appl. Chem. Vol.
73, No. 2, pp. 239-242 (2001)
Pure and Applied
Vol. 73, Issue
Some newer aspects of organozirconium chemistry of relevance to
organic synthesis. Zr-Catalyzed enantioselective carbometallation*
Herbert C. Brown Laboratories of Chemistry, Purdue
University, West Lafayette, Indiana 47907-1393, USA
Abstract: The reaction of terminal alkenes with trialkylalanes
in the presence of chiral (NMI) 2ZrCl2 has been
shown to be 70-75% ee for methylalumination and 90-95% ee for ethyl-
and higher alkylalumination. It must involve an acyclic bimetallic process.
Its scope, limitations, and applications to some natural products syntheses
* Lecture presented at the XIXth International Conference
on Organometallic Chemistry (XIX ICOMC) , Shanghai, China, 23-28 July
2000. Other presentations are published in this issue, pp. 205-376.
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