Chemistry International Blank Image
Chemistry International Text Image Link to Chemistry International Blank Image Chemistry International Blank Image Chemistry International Blank Image
Chemistry International Blank Image
Chemistry International Blank Image
Chemistry International Text Image Link to Current Issue
Chemistry International Text Image Link to Past Issues
Chemistry International Text Image Link to Officer's Columns
Chemistry International Text Image Link to Features
Chemistry International Blank Image
Chemistry International Text Image Link to Up for Discussion
Chemistry International Text Image Link to IUPAC Wire
Chemistry International Text Image Link to Project Place
Chemistry International Text Image Link to imPACt
Chemistry International Text Image Link to Bookworm
Chemistry International Text Image Link to Internet Connections
Chemistry International Text Image Link to Conference Call
Chemistry International Text Image Link to Where 2B and Y
Chemistry International Text Image Link to Symposia
Chemistry International Text Image Link to CI Indexes
Chemistry International Text Image Link to CI Editor
Chemistry International Text Image Link to Search Function
Chemistry International Text Image Link to Information

 

Chemistry International Text Image Link to Previous Issue Chemistry International Text Image Link to Previous Page Chemistry International Text Image Link to This TOC Chemistry International Text Image Link to Next Page Chemistry International Text Image Link to Next Issue

Vol. 34 No. 4
July-August 2012

Stamps International |

See also www.iupac.org/publications/ci/indexes/stamps.html


To Sneeze or Not To Sneeze

Allergies, among the most common ailments in the world, are abnormal reactions of the immune system that take place in response to otherwise harmless substances. Mild allergies often arise from exposure to widespread environmental allergens such as dust and pollen, which cause the red eyes, itchiness, and runny nose characteristic of hay fever. However, more severe allergic reactions may occur in some individuals, for example, upon ingestion of certain foods (e.g., peanuts), administration of penicillin or other antibiotics, or direct contact with the venom of stinging insects such as wasps and bees. Whether inhaled, ingested, or absorbed into the bloodstream, the offending substances trigger the release of copious amounts of histamine, an organic nitrogen compound derived from the amino acid histidine. Histamine is a potent vasodilator that increases the permeability of capillaries and leads to swelling of the affected tissues, redness, nasal congestion, sneezing, and other classic symptoms associated with allergic reactions. Most antihistamine drugs used in the treatment of allergies work by blocking the attachment of histamine to its cellular receptors and thus suppressing the ensuing inflammatory response. Interestingly, other histamine antagonists operate instead by inhibiting the activity of histidine decarboxylase, the enzyme that catalyzes the biosynthesis of histamine.

The stamp illustrated in this note, issued in 2008, shows the structural formula of histamine and honors Daniel Bovet (1907-1992), the Swiss-born Italian pharmacologist who discovered the first antihistamine in 1937 while working at the Pasteur Institute in Paris. His seminal studies on the pharmacology of a vast range of substances that affect the function of the central nervous system, including acetylcholine, adrenaline, and curare, a generic name used to describe various paralyzing South American arrow poisons, were recognized with the Nobel Prize in Physiology or Medicine in 1957. He published more than 300 papers, became a member of multiple learned societies, and is universally regarded as one of the forefathers of modern pharmacodynamics and mechanistic pharmacology.

Written by Daniel Rabinovich <[email protected]>.


Page last modified 10 July 2012.
Copyright © 2003-2012 International Union of Pure and Applied Chemistry.
Questions regarding the website, please contact [email protected]
Link to CI Home Page Link to IUPAC E-News Link to IUPAC Home Page