25 No. 2
Implications of Endocrine Active Substances
International SCOPE/IUPAC Symposium on Endocrine Active Substances
(EASs), held 1721 November 2002 in Yokohama, Japan,
was a major milestone in the project coordinated by the Chemistry
and the Environment Division and led by Dr. Junshi Miyamoto.
(SCOPE is the Scientific Committee on Problems of the Environment
of the International Council for Science.) The project objectives
are to critically evaluate the issues relating to the effects
of EASs on man and the environment, to prioritize research
needs, and to offer some manageable actions facilitating risk
assessment and risk communication. The symposium was organized
around four major topics:
molecular mode of action of nuclear receptors
environmental fate and metabolism of EASs
toxicological effects of EASs and risk assessment for humans
effects of EASs in wildlife species
international experts were invited to cover these issues in
a total of 55 sub-topics and there were 6 supplementary workshops
addressing related issues. Additionally there were poster
sessions for submitted papers and for the 55 main, orally
presented sub-topics (a rather unique, but effective way of
encouraging dialogue). The excellent facilities of the Yokohama
Convention Center proved equal to the task of accommodating
over 350 participants. The culmination of the project will
be the publication during 2003 of the final report in Pure
and Applied Chemistry containing the 55 manuscripts for
the sub-topics (with conclusions and recommendations) and
an executive summary.
are underway to improve EAS exposure assessments in
humans and animals.
overall recommendations for risk management of EASs are as
Environmental monitoring programs should be focused on high
priority EASs, including relevant metabolites, and be designed
to support exposure assessment.
correlations for chemical analyses and bioassays (TIE) should
be used to reevaluate the biological relevance of target
EASs for monitoring programs.
In addition to source control, available technologies for
reducing environmental entry should also be considered.
priorities to improve exposure assessment of humans and
wildlife are as follows:
increased reliability of detection methods for EASs
elucidation of metabolic pathways, including potential activation
key environmental fate parameters should be generated for
highly active EASs (e.g., steroid hormones, certain industrial
improved models for exposure assessments
development of more efficient processes for reducing environmental
this timely project of broad and far-reaching scope will result
in authoritative reviews, conclusions, and recommendations
for all topics important to understanding significance of
EASs. Publication in Pure and Applied Chemistry is
planned for 2003. The symposium was a very successful step
in progressing toward these objectives.
project update was prepared by Patrick T. Holland <[email protected]>,
secretary of the Chemistry and the Environment Division. For
more information contact Dr. Junshi Miyamoto <[email protected]>.
last modified 6 March 2003.
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