>Exec. Director's Column
>AOAC's Experience
>Small-Scale Chemistry
Young Scientist Awards
>IUPAC Projects
>Provisional Recommendations
>Highlights from PAC
>New Books
>Reports from Conferences
>Conference Announcements
>Conference Calendar

Download the May
issue in pdf format.
(2.19 MB)


CI Homepage

Chemistry International
Vol. 24, No. 3
May 2002


IUPAC Projects

Recommendation on the Use of Countercurrent Chromotography in Analytical Chemistry

IUPAC has approved a two-year project to prepare a critical review of applications of countercurrent chromatography (CCC) in organic and inorganic analytical chemistry, pharmaceutical industry, and in radiochemistry. The project will place an emphasis on theory, methodology, and instrumentation. Recommendations will be made on the terminology and standardization, taking into account its relative position between other extraction and chromatography processes.

CCC is used as a method for the concentration, separation, and purification of chemical and pharmaceutical substances at both analytical and process (production) scales based on their partition between two immiscible solvent phases. One liquid phase is held stationary in the force field of a coil planet centrifuge while the other is eluted through it as the mobile phase. Among its various advantages is the ability to achieve high-resolution extractions/separations with minimal solvent use.

The application of CCC in analytical chemistry has been investigated for 16 years at a fundamental level at the Vernadsky Institute of Geochemistry and Analytical Chemistry at the Russian Academy of Sciences. Various applications of CCC to the concentration and separation of a number of elements in environmental and inorganic analysis (including the purification of chemical reagents) have been studied and a fundamental understanding of the hydrodynamics is developing. It is also clear that a basis for developing various methods of analysis has been established from the applications of CCC in the pharmaceutical industry, particularly in the production of drugs, and through the equipment made at the Brunel Institute of Bioengineering, UK, and at other research and development institutions.

The aim of this proposal is to survey emerging technologies and applications based on CCC, including the progress made in the pharmaceutical industry, radiochemistry, and analytical and through preparative-scale inorganic separations.

Comments from the chemistry community are welcome and should be addressed to the project coordinator Prof. B.Spivakov, Vernadsky Institute of Geochemistry and Analytical Chemistry, Russian Academy of Sciences, Kosygin Str. 19, Moscow, Russia 119991, Tel.: +7 095 137 82 63, Fax: +7 095 938 20 54, E-mail: [email protected].





News and Notices - Organizations and People - Standing Committees
Divisions - Projects - Reports - Publications - Symposia - AMP - Links
Page last modified 5 May 2002.
Copyright © 1997-2002 International Union of Pure and Applied Chemistry.

Questions or comments about IUPAC, please contact the Secretariat.
Questions regarding the website, please contact [email protected]