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Chemistry and Human Health Division (VII)


Number: 2004-025-1-700

Title: Compendium of targets of the top 100 commercially important drugs

Task Group
John Proudfoot

Members: Erika Alapi, Janos Fischer, Stefan Jaroch, Susan Dana Jones, Michael Liebman, Tom Perun, Mark Samuels, and Attila Szemzo

Completion Date: 2006 - project terminated

To provide a compendium of the biological targets of the top 100 drugs.

A recent article (Fixing the Drugs Pipeline, The Economist March 11 2004) indicated that the 100 best selling target 43 gene products. However there does not appear to be a resource where compiled target information is readily available in a single source. The intention is to provide a resource containing the following information on commercially important drug targets: type of target (enzyme, receptor etc); brief description of relevance to disease treated; reference to knockout information, if available; reference to structural information, if available; listing of the marketed drugs that interact with the target along with potency and relevant selectivity information.

Dec 2006: project terminated - the project has been pre-empted by the publication of the DrugBank database, carrying all the information on Molecular Targets for Drugs.
> access the DrugBank <http://redpoll.pharmacy.ualberta.ca/drugbank/>
>> review in Chem Int. May/June 2007


Last Update: 16 June 2007

<project announcement published in Chem. Int. Jan/Feb 2005>


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Page last modified 16 June 2007.
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