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Chemistry and Human Health Division (VII)


Number: 2003-028-1-700

Title: Glossary for chemists of terms used in toxicology - revision and updating

Task Group
J. Duffus

Members: M. Nordberg and D. M. Templeton

Completion Date: 2007 - project completed

IUPAC is the world authority on chemical nomenclature and terminology. Toxicology is a subject area dependent on good chemistry and itself influences chemistry through its impact on legislation for chemical safety. IUPAC has long recognised this fact and in 1993 published a Glossary for Chemists of Terms Used in Toxicology as an IUPAC Recommendation. This Glossary has received wide recognition as authoritative and, in particular, has been adopted by the U.S. National Institutes of Health as the glossary for its TOXNET website. This website is now being updated and the Task Group Chairman (above) has been asked if the existing IUPAC Glossary is being revised and brought up to date. This is clearly necessary since toxicology has developed considerably in the 11 years since the glossary was published. The need for a glossary in toxicokinetics, recognised by IUPAC in another project (project number #2000-034-2-700), is a symptom of the need to revise and expand the existing glossary of terms used in toxicology.

The objective of this project is to create a revised "Glossary for Chemists of Terms Used in Toxicology". The revised glossary will incorporate essential terms from the new Glossary of Terms in Toxicokinetics, review existing definitions, and add new terms which have come into common use since the original glossary was compiled. It is proposed to seek input widely and to co-operate with the U.S, National Institutes of Health National Library of Medicine so that the revised glossary can link effectively into their Toxnet system and be hyperlinked to the educational resource Tox Tutor on their website. This will help to ensure wide use of the Glossary. Acceptance of this Glossary as a global tool to serve chemists and others will have an impact on a number of scientific fields and help to maintain a good image of both IUPAC and of chemistry in society generally.

This Glossary in its revised version will cover all terms relevant to toxicology and bring them together in one source document for ease of use. It will include new terms and more terms in toxicokinetics identified and defined in the recent project which produced a glossary of terms in toxicokinetics. It will also cover essential terms relevant to risk assessment of chemical use.

May 2005 - The draft which had been circulated by John Duffus was reviewed, with valuable comments from Mike Schwenck. The glossary of terms in toxicokinetics has been included and terms revised in this glossary replaced the 1993 terminology. New terms introduced by the rapid development of toxicogenomics were added and the definitions refined to the agreement of the group. Terms related to endocrine disruption were also added.
A revised draft, with annotations, will circulate among the task group for further consideration.

April 2006 - A manuscript is being prepared for publication in Pure Appl. Chem. A final document is submitted to public review comments until 30 Sep 2006.
> provisional recommendations [reports/provisional/abstract06/duffus_300906.html]

Project completed - IUPAC Recommendations published in Pure Appl. Chem. 79(7), 1153-1344, 2007

Last Update: 2 July 2007


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