Title: Solubility data of compounds relevant to human health.
Solubility of hydroxybenzoic acids and hydroxybenzoates
Series: Solubility Data Series; editor-in-chief: Mark
Chairmen: A. Goto
and H. Miyamoto
Hydroxybenzoic acids and related compounds are pharmaceutically important
substances. In particular, 2-hydroxybenzoic acid has been widely used
as a medicine and a preservative for food products; 4-hydroxybenzoic
acid alkyl esters have also been used as preservatives for food. The
relation between the use of these substances and human health requires
evaluation of the solubilities of 2-, 3-, and 4-monohydroxybenzoic acids
and of 4-hydroxybenzoic acid alkyl esters in water, organic and mixed
solvents. It is also suggested to evaluate the solubilities of: (a)
2- and 3-hydroxybenzoic acid in supercritical carbon dioxide containing
organic solvents such as methanol and acetone; (b) monohydroxybenzoates,
2,3-, 2,4-, 2,5-, 2,6-, 3,4- and 3,5- dihydroxybenzoic acid salts of
alkali, transition and rare earth metals in water and organic solvents.
All of the solubility data of hydroxyl benzoic acids and hydroxybenzoates
have been compiled. A total of 177 original studies treating ternary
systems published from 1898 to 2001 has been carried out. The solubilities
of hydroxyl benzoic acids and alkyl p hydroxybenzoates in water and
in various alcohols could be statistically evaluated at various temperatures.
> Nov 2004 report update (pdf
file - 11KB)
> May 2006 report update (pdf
file - 14KB)
To be published as part of the IUPAC-NIST Solubility Data Series. in
J. Phys. Chem. Ref. Data.
> July 2007 report update (pdf
file - 13KB)
Last Update: 16 October 2007
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