I  U  P  A  C

News & Notices

Organizations & People

Standing Committees







Links of Interest

Search the Site

Home Page



Current Project

Analytical Chemistry Division (V)


Number: 2002-036-1-500

Title: Solubility data of compounds relevant to human health. Solubility of hydroxybenzoic acids and hydroxybenzoates

Series: Solubility Data Series; editor-in-chief: Mark Salomon

Task Group
A. Goto and H. Miyamoto

Hydroxybenzoic acids and related compounds are pharmaceutically important substances. In particular, 2-hydroxybenzoic acid has been widely used as a medicine and a preservative for food products; 4-hydroxybenzoic acid alkyl esters have also been used as preservatives for food. The relation between the use of these substances and human health requires evaluation of the solubilities of 2-, 3-, and 4-monohydroxybenzoic acids and of 4-hydroxybenzoic acid alkyl esters in water, organic and mixed solvents. It is also suggested to evaluate the solubilities of: (a) 2- and 3-hydroxybenzoic acid in supercritical carbon dioxide containing organic solvents such as methanol and acetone; (b) monohydroxybenzoates, 2,3-, 2,4-, 2,5-, 2,6-, 3,4- and 3,5- dihydroxybenzoic acid salts of alkali, transition and rare earth metals in water and organic solvents.

All of the solubility data of hydroxyl benzoic acids and hydroxybenzoates have been compiled. A total of 177 original studies treating ternary systems published from 1898 to 2001 has been carried out. The solubilities of hydroxyl benzoic acids and alkyl p hydroxybenzoates in water and in various alcohols could be statistically evaluated at various temperatures.
> Nov 2004 report update (pdf file - 11KB)

> May 2006 report update (pdf file - 14KB)

To be published as part of the IUPAC-NIST Solubility Data Series. in J. Phys. Chem. Ref. Data.

> July 2007 report update (pdf file - 13KB)

Last Update: 16 October 2007

> View SDS published Volumes

<project announcement published in Chem. Int. 25(3), 2003>

If you want to update this information, contact us by e-mail
Do not forget to include the Project Number,
your name and relation with that project

Page last modified 16 October 2007.
Copyright ©1997-2007 International Union of Pure and Applied Chemistry.
Questions or comments about IUPAC, please contact, the Secretariat.
Questions regarding the website, please contact Web Help.