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Organic and Biomolecular Chemistry Division (III)
Chemistry and Human Health Division (VII)


Number: 2001-005-1-300

Title: Post-genomic chemistry

Task Group
Sergey D. Varfolomeyev

Members: I. Beletskaya, I. Bertini, M. Blackburn, R. Cunin, E. Efremenko, J. Eichler, I. Galaev, V. Gladyshev, T. Haertle, A. Karyakin, I. Kurochkin, M. Mikolajczyk, V. Poroikov, I. Sakharov, F. Spener, N. Voyer, and J. Wild

Completion Date: 2005 - project completed

The objective is the analysis and discussion of the most promising areas of bioorganic chemistry exploiting the informations provided by the recent advances of functional genomics. Other objectives will aim widest possible integration of research groups working in this area. The network promoting worldwide collaboration and innovation in this area will be organized during this conference.

Knowledge of human genome and of those of other organisms creates number of new avenues for natural sciences. The main aim of the proposed project is to analyze present and future impact of information yielded by functional genomics on the modern chemistry and bioorganic chemistry in particular. The principal axis of the conference will focus on the analysis and exploitation of this information for the improvement of human health. Specific working panels will be assembled to analyze and discuss the following topics:

  1. Post-genomic strategies for drug design.
  2. Protein chemistry: sequence - structure - function relationships.
  3. Proteins containing chemically modified amino acids: (natural proteins containing unnatural amino acids).
  4. Post-genomic biocatalysis: identification of the enzyme active sites and prediction of catalytic properties from gene sequences.
  5. Multi-array analysis. New protein and DNA biochip technologies.
  6. Non-invasive monitoring of blood chemistry.
  7. 'In silico' modeling of a cell: construction of "living" cells in computer. Biokinetic computer models for studies of gene expression and metabolism.

This project was presented at a poster session at the IUPAC Congress/GA July 2005
>view pdf - 50KB<

In developing this project, a mini-workshop was held 6–8 September 2003 in Moscow, which allowed experts to exchange views on chemistry in the post genomic era. In particular, they discussed the implication of advances in genomics, proteomics, biomimetics, and biological and chemical informatics
> See update as reported in Chem. Int. March 2004

Project completed - IUPAC Technical Report published in Pure Appl. Chem. 77(9), 1641-1654, 2005

Last update: 3 October 2005

Page last modified 3 October 2005.
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